DONOR CHARACTERISTICS AFFECTING GRAFT FAILURE, GRAFT vs. HOST DISEASE AND SURVIVAL AFTER UNRELATED DONOR TRANSPLANTATION WITH REDUCED INTENSITY CONDITIONING FOR HEMATOLOGIC MALIGNANCIES
Identifieur interne : 006182 ( Main/Exploration ); précédent : 006181; suivant : 006183DONOR CHARACTERISTICS AFFECTING GRAFT FAILURE, GRAFT vs. HOST DISEASE AND SURVIVAL AFTER UNRELATED DONOR TRANSPLANTATION WITH REDUCED INTENSITY CONDITIONING FOR HEMATOLOGIC MALIGNANCIES
Auteurs : Jakob R. Passweg [Suisse] ; Mei-Jie Zhang [États-Unis] ; Vanderson Rocha [France] ; Fangyu Kan [États-Unis] ; Richard E. Champlin [États-Unis] ; Luis M. Isola [États-Unis] ; Adrian P. Gee [États-Unis] ; John Gibson [Australie] ; Mary J. Laughlin [États-Unis] ; Hillard M. Lazarus [États-Unis] ; Alison Loren [États-Unis] ; David I. Marks [Royaume-Uni] ; Alois Gratwohl [Suisse] ; Mary Eapen [États-Unis]Source :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1083-8791 ] ; 2011.
Abstract
We examined the effect of donor characteristics on graft failure (<5% donor chimerism within 3 months after transplantation), acute and chronic graft-versus-host disease (GVHD) and survival after unrelated donor reduced intensity conditioning (RIC)transplantation in 709 patients with hematologic malignancies. Donor-recipient pairs were HLA typed at HLA-A, -B, -C, -DRB1 (allele-level). Five hundred and one patients were >95% donor chimerism, 145 patients, 5–95% and 63 patients <5%. The only donor characteristic associated with transplant-outcome was donor-recipient HLA matching. One or two-loci mismatched transplants led to higher grade 2–4 (RR 1.27, p=0.035) and grade 3–4 (RR 1.85, p<0.001) acute GVHD and two-loci mismatched transplants, higher mortality (RR 2.22, p<0.001). Graft failure was higher after transplantation of bone marrow (RR 2.33, p=0.002). Donor age, parity and donor sex match were not associated with transplant-outcome. Donor-recipient HLA-matching is the only donor characteristic predictive for survival after RIC regimens for hematologic malignancies.
Url:
DOI: 10.1016/j.bbmt.2011.07.008
PubMed: 21771571
PubMed Central: 3217167
Affiliations:
- Australie, France, Royaume-Uni, Suisse, États-Unis
- Minnesota, Ohio, Pennsylvanie, Texas, Virginie, Wisconsin, État de New York, Île-de-France
- Paris
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Passweg</name><affiliation wicri:level="1"><nlm:aff id="A1">University Hospital Basel, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Mei Jie" sort="Zhang, Mei Jie" uniqKey="Zhang M" first="Mei-Jie" last="Zhang">Mei-Jie Zhang</name><affiliation wicri:level="2"><nlm:aff id="A2">Medical College of Wisconsin, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Medical College of Wisconsin</wicri:cityArea></affiliation></author><author><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name><affiliation wicri:level="3"><nlm:aff id="A3">Hopital Saint Louis, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hopital Saint Louis, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kan, Fangyu" sort="Kan, Fangyu" uniqKey="Kan F" first="Fangyu" last="Kan">Fangyu Kan</name><affiliation wicri:level="2"><nlm:aff id="A4">National Marrow Donor Program, Minneapolis, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>National Marrow Donor Program, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Champlin, Richard E" sort="Champlin, Richard E" uniqKey="Champlin R" first="Richard E." last="Champlin">Richard E. Champlin</name><affiliation wicri:level="2"><nlm:aff id="A5">MD Anderson Cancer Center, Houston, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Isola, Luis M" sort="Isola, Luis M" uniqKey="Isola L" first="Luis M." last="Isola">Luis M. Isola</name><affiliation wicri:level="2"><nlm:aff id="A6">Mount Sinai Medical Center, New York, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Mount Sinai Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Gee, Adrian P" sort="Gee, Adrian P" uniqKey="Gee A" first="Adrian P." last="Gee">Adrian P. Gee</name><affiliation wicri:level="2"><nlm:aff id="A7">Baylor College of Medicine, Houston, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Gibson, John" sort="Gibson, John" uniqKey="Gibson J" first="John" last="Gibson">John Gibson</name><affiliation wicri:level="1"><nlm:aff id="A8">Royal Prince Alfred Hospital, Camperdown, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Prince Alfred Hospital, Camperdown</wicri:regionArea><wicri:noRegion>Camperdown</wicri:noRegion></affiliation></author><author><name sortKey="Laughlin, Mary J" sort="Laughlin, Mary J" uniqKey="Laughlin M" first="Mary J." last="Laughlin">Mary J. Laughlin</name><affiliation wicri:level="2"><nlm:aff id="A9">University of Virginia Health Systems, Charlottesville, VA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>University of Virginia Health Systems, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name><affiliation wicri:level="2"><nlm:aff id="A10">University Hospitals Case Medical Center, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>University Hospitals Case Medical Center, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Loren, Alison" sort="Loren, Alison" uniqKey="Loren A" first="Alison" last="Loren">Alison Loren</name><affiliation wicri:level="2"><nlm:aff id="A11">Hospital of the University of Pennsylvania, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Hospital of the University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name><affiliation wicri:level="1"><nlm:aff id="A12">United Bristol Healthcare Trust., Bristol, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>United Bristol Healthcare Trust., Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Gratwohl, Alois" sort="Gratwohl, Alois" uniqKey="Gratwohl A" first="Alois" last="Gratwohl">Alois Gratwohl</name><affiliation wicri:level="1"><nlm:aff id="A1">University Hospital Basel, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Eapen, Mary" sort="Eapen, Mary" uniqKey="Eapen M" first="Mary" last="Eapen">Mary Eapen</name><affiliation wicri:level="2"><nlm:aff id="A2">Medical College of Wisconsin, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Medical College of Wisconsin</wicri:cityArea></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="ISSN">1083-8791</idno><idno type="eISSN">1523-6536</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">We examined the effect of donor characteristics on graft failure (<5% donor chimerism within 3 months after transplantation), acute and chronic graft-versus-host disease (GVHD) and survival after unrelated donor reduced intensity conditioning (RIC)transplantation in 709 patients with hematologic malignancies. Donor-recipient pairs were HLA typed at HLA-A, -B, -C, -DRB1 (allele-level). Five hundred and one patients were >95% donor chimerism, 145 patients, 5–95% and 63 patients <5%. The only donor characteristic associated with transplant-outcome was donor-recipient HLA matching. One or two-loci mismatched transplants led to higher grade 2–4 (RR 1.27, p=0.035) and grade 3–4 (RR 1.85, p<0.001) acute GVHD and two-loci mismatched transplants, higher mortality (RR 2.22, p<0.001). Graft failure was higher after transplantation of bone marrow (RR 2.33, p=0.002). Donor age, parity and donor sex match were not associated with transplant-outcome. Donor-recipient HLA-matching is the only donor characteristic predictive for survival after RIC regimens for hematologic malignancies.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Minnesota</li><li>Ohio</li><li>Pennsylvanie</li><li>Texas</li><li>Virginie</li><li>Wisconsin</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="Suisse"><noRegion><name sortKey="Passweg, Jakob R" sort="Passweg, Jakob R" uniqKey="Passweg J" first="Jakob R." last="Passweg">Jakob R. Passweg</name></noRegion><name sortKey="Gratwohl, Alois" sort="Gratwohl, Alois" uniqKey="Gratwohl A" first="Alois" last="Gratwohl">Alois Gratwohl</name></country><country name="États-Unis"><region name="Wisconsin"><name sortKey="Zhang, Mei Jie" sort="Zhang, Mei Jie" uniqKey="Zhang M" first="Mei-Jie" last="Zhang">Mei-Jie Zhang</name></region><name sortKey="Champlin, Richard E" sort="Champlin, Richard E" uniqKey="Champlin R" first="Richard E." last="Champlin">Richard E. Champlin</name><name sortKey="Eapen, Mary" sort="Eapen, Mary" uniqKey="Eapen M" first="Mary" last="Eapen">Mary Eapen</name><name sortKey="Gee, Adrian P" sort="Gee, Adrian P" uniqKey="Gee A" first="Adrian P." last="Gee">Adrian P. Gee</name><name sortKey="Isola, Luis M" sort="Isola, Luis M" uniqKey="Isola L" first="Luis M." last="Isola">Luis M. Isola</name><name sortKey="Kan, Fangyu" sort="Kan, Fangyu" uniqKey="Kan F" first="Fangyu" last="Kan">Fangyu Kan</name><name sortKey="Laughlin, Mary J" sort="Laughlin, Mary J" uniqKey="Laughlin M" first="Mary J." last="Laughlin">Mary J. Laughlin</name><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name><name sortKey="Loren, Alison" sort="Loren, Alison" uniqKey="Loren A" first="Alison" last="Loren">Alison Loren</name></country><country name="France"><region name="Île-de-France"><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name></region></country><country name="Australie"><noRegion><name sortKey="Gibson, John" sort="Gibson, John" uniqKey="Gibson J" first="John" last="Gibson">John Gibson</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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